SRSP2 – 1

Duplicate Submission

2023 Mentor Project Submission Created: Feb 13, 2023

First Name

Last Name

Degree

E-Mail

Phone Number

School

Department

Type of Research:

Project Title

IRB Required?

IRB Status

IRB Approval #

Training

Mentor/supervisor training completed?

HIPPA

CITI

IACUC Required?

IACUC Status

IACUC Approval #

Project Involves

Tuberculosis

Cancer

Multiple

Cardiovascular

Performance Site(s)

Will research be conducted at our partner hospitals?

Nortons's HealthCare Hospitals

Kosair Childrens Hospital

Jewish and St. Mary's Hospital

VA Medical Center

Stipend

This entry will be supplied by the HSC Research Office

Previous Students

Medical students who have done summer research with you in the past.

Direct Contact

How much direct contact do you expect to have with the student in hours/week?

Supervision

Who will provide the direct daily supervision of the student and indicate, and what is their position and background (faculty, postdoc, lab tech, nurse practitioner, clinical fellow, etc.)?

Prospective Students

If you have identified one or more prospective SRSP students you would like to have work on this research project this coming summer, please provide the student's name(s).

Expected Activity Breakdown

Indicate the percentage time that student can expect to spend on the following types of activities, total must come to 100%.

Clinical study with patient contact – See Human Subjects requirement approval above

Live or in vivo animal studies – See IACUC approval requirement above

Laboratory bench studies, in vitro experiments, etc…

Chart review, interview or survey reviews

Computer modeling, data analysis, spreadsheets, etc…

Library work

Other

Total – Must be 100%

Project Description

The incidence of colon cancer (CC) in patients younger than 50 years of age has increased by more than 30% in the U.S. since the 1990s. Obesity prevalence has been continuously rising, and obesity contributes to a systemic tumor-promoting proinflammatory state in CC. Peripheral Blood Mononuclear Cells (PBMCs) are inflammatory cells that can be recruited into tumors to form macrophages. In CC, tumor-derived cytokines can affect macrophage differentiation and carcinogenic function to enhance tumor development. PBMCs can alter their gene expression profile while circulating and may function as CC screening markers. Pro- and anti-inflammatory genes play a role in tumor-promoting macrophages and CC progression and can predispose individuals to give rise to carcinogenic macrophages in tumor tissue and therefore CC onset. Inflammatory macrophage markers and transcription factors are associated with prognosis and recurrence rate in patients with CC. The aim of this study is to expand upon previous pilot work examining the gene expression profile of inflammatory markers in PBMCs of patients with a diagnosis of sporadic CC compared to healthy controls, particularly looking at young and obese patients.

What will the student be doing?

Please be as specific as possible to assist the students in understanding how they will be involved in the research project

References

You may provide several references that will help prospective students better understand your proposed project